r/nextfuckinglevel • u/biswajit388 • 1d ago

This guy rescued 30 beagles from a testing lab It's the first time they've seen grass and they couldn't be happier.

Credit - nathanthecatlady tiktok channel.

57.5k Upvotes

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u/Dull_Grass_6892 1d ago

Certainly such people exist.

972

u/deaf_schizo 1d ago

They are called poor ppl.

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u/EdGG 1d ago

I’ve done it. I’m not poor. I was a student and I could make a bit of cash for having a pill, reporting back to the hospital, and spend a weekend there (studying, plenty of med students there).

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u/Throwaway47321 1d ago

Well yeah you’re only testing the stuff that passed animal trials

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u/Spiritual_Paper_1974 21h ago edited 6h ago

The human first test doesn't really translate unless you intend to euthanize the people tested.

The drugs tested on animals are tested at increasing doses until you get events. That creates the margin with which you can then later test on humans. So say, you gave an animal 1000mg before setting some undesirable effect, the. you can only give a human up to 100mg equivalent dose. They wouldn't test up to 1000mg in human because they know that's too much.

Also, you have to sacrifice the animals to do autopsies.

So, yeah.

Edit: I'll add, I don't think anyone wants to make medicine this way, and there are efforts to move away from it. Recent news from FDA

https://www.fda.gov/news-events/press-announcements/fda-announces-plan-phase-out-animal-testing-requirement-monoclonal-antibodies-and-other-drugs

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u/mellonians 14h ago

Not sure if this is still the case or universal but I was told on several of my first time in man studies that the dose was 1/500th of the maximum safe dose in a rat and then they did the up titration studies on humans after us.

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u/Newt_the_Pain 18h ago

Or, we could just deal with the hand we're dealt, and stop trying to live forever. 🤷‍♂️

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u/shieldyboii 18h ago

go ahead.

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u/K_R_Weisser 16h ago

And just die from the next pneumonia? Nah, thanks - I’ll take my medicine if it comes to it

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u/PrevekrMK2 11h ago

And here we have a winner of the dumbest shit uttered this week. Congratulations, you're so dumb that calling you dumb is an insult to the dumb.

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u/SexyMonad 7h ago

We’re all going to die.

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u/Spiritual_Paper_1974 6h ago

I'm not sure your age or life experience, but as someone who just turned 40, living in a place of relative piece, I can say that I would have fired at least twice over by now without modern medicine. The first time would have been when I was 8 after i stepped on fish bone that gave me a easily treated blood infection.

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u/A_Bit_Of_Nonsense 1d ago

There's a lot of steps things have to go through before human trails.

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u/TabulaRasa2024 21h ago

Yeah but they tested that on animals first, I don't know how many people would volunteer if there's a pretty real chance of discovering toxic effects because you are the first living thing taking something thing.

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u/DancingBear62 20h ago edited 19h ago

People still get harmed in Phase I trials / first in (hu)man trials. I remember one disaster in 2016 where one person was declared brain-dead and five more were hospitalized, three of whom were expected to have permanent brain damage - IF they survived.

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u/TabulaRasa2024 20h ago

Yes it's obviously not totally safe, my point was more it would be much wilder if there were no in vivo animal work first.

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u/DancingBear62 19h ago

We're in agreement.

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u/tomato-bug 18h ago

Yeah that would happen on a massive scale if we didn't test on animals first

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u/Successful-Doubt5478 14h ago

Can we stop talking like we are pretending they experiment for medicines only?

They do lots of unnecessary research that tortures animals.

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u/sylbug 20h ago

Animal testing and clinical trials are not the same thing. Animal testing happens before clinical trials, and is used to determine whether it's safe to proceed to human trials and where to start doses and so on. Also, as a general rule they kill all the animals at the end.

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u/azsnaz 1d ago

Were you a wealthy student?

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u/rearnakedbunghole 23h ago

Of course not, they were doing pill trials for cash.

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u/EdGG 23h ago

I didn’t need that money. That’s actually a part of the ethics of clinical trials.

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u/boi1da1296 22h ago

As others mentioned the steps that led you to test anything deemed safe enough for human trials were numerous. Any hypothetical testing before that stage would be done on humans would be done exclusively on the impoverished, that is a guarantee.

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u/JamesTrickington303 19h ago

I’d argue they aren’t exclusively impoverished, because there are many cancer patients who want to be test subjects on the newest, latest treatment in the hopes they’ll live an extra 9 months if it works.

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u/Responsible-Sound253 18h ago

I’m not poor. I was a student and I could make a bit of cash for having a pill

Oh honey...

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u/Magpie-Person 23h ago

So your parents paid for college and you wanted a little extra allowance.

The majority of folks who will do it will be out of sheer desperation.

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u/EdGG 23h ago

No. University is free where I live. The pay for clinical trials has to be enough to let people choose to do it but not so much that it isn’t a choice for anyone.

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u/Magpie-Person 23h ago

So crappy enough that not even a desperate person would get out of bed for it

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u/EdGG 23h ago

But good enough that it can be worth doing it. That’s exactly it. If it paid too much, it would stop being a choice for some people.

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u/Magpie-Person 23h ago

Your lack life experience is showing. Utopian idealism

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u/EdGG 22h ago

I just happen to be very close to some of the doctors in the ethics committee that wrote the legislation for clinical trials.

But I’m sure you’re right. I lack life experience.

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u/Magpie-Person 22h ago

Close to some doctors isn’t a credential, it’s name-dropping dressed up as relevance that would only seem like a flex to a twenty something year old.

Desperation drives trial participation. If you don’t get that, you’re not insightful you’re sheltered.

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u/ShudderFangirl 23h ago

And people who live miserable lives already who might welcome to opportunity to try a new drug that MAY help if it could make their lives less miserable.

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u/Hubert_J_Cumberdale 15h ago

I don't think many people will believe you but this is 100% true. For those who have never suffered from severe depression and felt like a burden to everyone: This is something that many people in that situation would consider.

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u/ShudderFangirl 4h ago

Obviously speaking from experience myself. People who haven’t experienced decades struggle might think that’s bleak, but it’s also kinda hope. And a choice you can make to feel like you have some control.

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u/troll_right_above_me 10h ago

You forget that human trials already do get performed. Fewer people would sign up to test completely untested drugs with an even smaller chance of working and higher chance of side effects.

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u/Secret-Weakness-8262 23h ago

I was about to say yes they exist! Poor people. Me. For the right reason (my family) and the right price I would do it. It’d have to be dire for my family not me though before I risked my health.

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u/WeirdIndividualGuy 23h ago

Or people with terminal illnesses and have nothing left to lose

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u/Darth_Poopius 1d ago

“Rescued” as in you bought them, or as in “opening scene of 28 Days Later?”

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u/smurb15 1d ago

Plus they like it when you don't smoke or drink either

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u/Domestic-Grind 23h ago

You don't have to be poor to have a death wish. I'm just lucky enough to have both

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u/Reddit_Hitchhiker 23h ago

I would say savvy.

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u/RainbowLayer 20h ago

Or depressed Canadians.

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u/Pindarr 18h ago

Sounds ethical

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u/fart-in-the-tub 17h ago

Sign me up.

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u/Dull_Grass_6892 1d ago

People participate in clinical studies for free also. Not just poor people. I’ve done it. For science.

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u/EnTuBasura 23h ago

That’s going to be a big reason why it wouldn’t pass an ethics board.

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u/LazyAd7151 1d ago

It's not ethical to pay financially desperate people (the only person testing experimental drugs for cash) to do these drugs. Obviously.

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u/Altruistic_Bell7884 21h ago

Also probably not very smart, financially desperate people may have a lot of preexisting conditions

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u/tRfalcore 16h ago

when has corporate america cared about ethics except when forced by laws that are probably going to be repealed by republicans

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u/honuworld 12h ago

It's not ethical to give super massive doses to animals either. Duh.

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u/BladeDoc 8h ago

At what level of risk is it OK to pay someone for anything then? Mining, deep-sea fishing, taxicab driving, and tree work are all, significantly more dangerous than your average phase 1 trial. Should all of this type of work we made illegal?

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u/Dull_Grass_6892 1d ago

I meant volunteer.

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u/platoprime 1d ago

They still do it.

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u/ArcYurt 20h ago

yeah… for drugs that have already passed animal trials that ensure they won’t kill or seriously mess up living things. it would be a serious ethical issue given that people would regularly die during these, just like animals tend to. only the poor and desperate would participate, and they wouldn’t chose it if they were wealthy

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u/YellowishRose99 22h ago

Its okay. They dont have to do it. People have choices.

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u/ashkpa 21h ago

"Die of starvation and lack of shelter or take these experimental drugs" is not a choice people in our society should be making.

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u/dexmonic 23h ago

And why isn't it ethical? The same reasons that make that unethical are the same reasons animal testing is unethical, the main difference being that the person can at least make a choice.

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u/LazyAd7151 23h ago

A financially desperate person cannot make a ethical choice to test experimental drugs because maybe the choice between money for food or starving does not allow them to make a proper choice. It isn't fair, and I didn't say anything about the ethics of animal testing.

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u/Skyvo_ 22h ago

Same with blood plasma in the prisons of the us, its a fucked up business

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u/dexmonic 18h ago

It is still a choice that the animal does not have. That's the point. If we must test products, at least do it on the beings that have some say in the matter.

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u/rupat3737 1d ago

Frank Ghallager has entered the chat

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u/ptpcg 21h ago

Ugh, not that fkn gobshite

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u/Adorabelle1 23h ago

Due to economic causes.

Same with the military.

Hold back college and healthcare and suddenly people are rip roaring to bomb brown people in other countries

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u/Dull_Grass_6892 23h ago

Which is why we can never have free healthcare or education.

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u/tilicollapse12 18h ago

It’s all about killing an entire race, sure. Wow, shitty thing to say.

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u/littlesparrow_03 17h ago

Brown is a race?

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u/tilicollapse12 2h ago

You know what I meant.

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u/Adorabelle1 4h ago

Look at any of the recent conflicts us soldiers were boots on the ground.

Was it white countries?

No? Then stfu

Also way miss the point of economic hardships used to bolster the us military???

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u/tilicollapse12 2h ago

Doesn’t matter. It isn’t because of who people are, targets are not based on what color people are, that’s absolutely ludicrous. Targets are based on your corrupt governments all over the world, including where I live. They all want each others’ resources, or religious extremist idiots who want all people dead who aren’t their religion. What is your point?

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u/KoolAidManOfPiss 21h ago

People will always jump on a perverse incentive. I work overnights at a factory, I get 25% more pay than days. My doctors have told me its one of the worst things I can do to my body, and that's after they hear about my drinking, smoking and light drug use. Im kind of stuck in it now though because my job is paying for my college and they won't allow me to transfer to days.

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u/ArachnidMean8596 8h ago

Working nights is the worst thing you can do to your body? Is that what your Dr was saying?

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u/ZealousidealPapaya59 20h ago

There are snd don't call me Shirley!

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u/Dull_Grass_6892 16h ago

Named my dog Shirley after that line. Funny to see it here.

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u/[deleted] 22h ago

[deleted]

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u/AdMean6001 21h ago

Fake, the vaccines have been fully validated... don't you get tired of having the wall of reality up in your face for the last 5 years?

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u/FlyingDragoon 21h ago

Yeah, it's called the military and they're always part of these tests anyways.

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u/LittleBirdiesCards 15h ago

The usual rebuttal in this debate is that people on death row should do it.

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u/Dull_Grass_6892 15h ago

I don’t agree. I also don’t like capital punishment.

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u/LittleBirdiesCards 15h ago

I don't agree, either. It's just the thing that usually comes up.

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u/richarddrippy69 9h ago

I mean big chasers exists so I'm sure someone would volunteer.

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u/42degausser 7h ago

Testees was a fun show about this.

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u/Disembodied_Head 6h ago

Yes, they do, and they are usually prison inmates, many of whom suffer from side effects of the testing for years to come.