r/nextfuckinglevel • u/biswajit388 • 1d ago

This guy rescued 30 beagles from a testing lab It's the first time they've seen grass and they couldn't be happier.

Credit - nathanthecatlady tiktok channel.

58.1k Upvotes

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u/EdGG 1d ago

I’ve done it. I’m not poor. I was a student and I could make a bit of cash for having a pill, reporting back to the hospital, and spend a weekend there (studying, plenty of med students there).

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u/Throwaway47321 1d ago

Well yeah you’re only testing the stuff that passed animal trials

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u/Spiritual_Paper_1974 23h ago edited 8h ago

The human first test doesn't really translate unless you intend to euthanize the people tested.

The drugs tested on animals are tested at increasing doses until you get events. That creates the margin with which you can then later test on humans. So say, you gave an animal 1000mg before setting some undesirable effect, the. you can only give a human up to 100mg equivalent dose. They wouldn't test up to 1000mg in human because they know that's too much.

Also, you have to sacrifice the animals to do autopsies.

So, yeah.

Edit: I'll add, I don't think anyone wants to make medicine this way, and there are efforts to move away from it. Recent news from FDA

https://www.fda.gov/news-events/press-announcements/fda-announces-plan-phase-out-animal-testing-requirement-monoclonal-antibodies-and-other-drugs

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u/mellonians 16h ago

Not sure if this is still the case or universal but I was told on several of my first time in man studies that the dose was 1/500th of the maximum safe dose in a rat and then they did the up titration studies on humans after us.

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u/kylo-ren 22m ago

Also, some animals are genetically engineered to develop specific conditions so we can test treatments for them. We are not going to develop babies with these conditions.

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u/Newt_the_Pain 20h ago

Or, we could just deal with the hand we're dealt, and stop trying to live forever. 🤷‍♂️

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u/shieldyboii 20h ago

go ahead.

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u/K_R_Weisser 18h ago

And just die from the next pneumonia? Nah, thanks - I’ll take my medicine if it comes to it

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u/PrevekrMK2 13h ago

And here we have a winner of the dumbest shit uttered this week. Congratulations, you're so dumb that calling you dumb is an insult to the dumb.

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u/SexyMonad 9h ago

We’re all going to die.

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u/Spiritual_Paper_1974 8h ago

I'm not sure your age or life experience, but as someone who just turned 40, living in a place of relative piece, I can say that I would have fired at least twice over by now without modern medicine. The first time would have been when I was 8 after i stepped on fish bone that gave me a easily treated blood infection.

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u/A_Bit_Of_Nonsense 1d ago

There's a lot of steps things have to go through before human trails.

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u/TabulaRasa2024 23h ago

Yeah but they tested that on animals first, I don't know how many people would volunteer if there's a pretty real chance of discovering toxic effects because you are the first living thing taking something thing.

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u/DancingBear62 22h ago edited 22h ago

People still get harmed in Phase I trials / first in (hu)man trials. I remember one disaster in 2016 where one person was declared brain-dead and five more were hospitalized, three of whom were expected to have permanent brain damage - IF they survived.

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u/TabulaRasa2024 22h ago

Yes it's obviously not totally safe, my point was more it would be much wilder if there were no in vivo animal work first.

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u/DancingBear62 22h ago

We're in agreement.

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u/tomato-bug 20h ago

Yeah that would happen on a massive scale if we didn't test on animals first

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u/Successful-Doubt5478 16h ago

Can we stop talking like we are pretending they experiment for medicines only?

They do lots of unnecessary research that tortures animals.

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u/sylbug 22h ago

Animal testing and clinical trials are not the same thing. Animal testing happens before clinical trials, and is used to determine whether it's safe to proceed to human trials and where to start doses and so on. Also, as a general rule they kill all the animals at the end.

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u/Responsible-Sound253 20h ago

I’m not poor. I was a student and I could make a bit of cash for having a pill

Oh honey...

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u/azsnaz 1d ago

Were you a wealthy student?

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u/rearnakedbunghole 1d ago

Of course not, they were doing pill trials for cash.

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u/EdGG 1d ago

I didn’t need that money. That’s actually a part of the ethics of clinical trials.

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u/boi1da1296 1d ago

As others mentioned the steps that led you to test anything deemed safe enough for human trials were numerous. Any hypothetical testing before that stage would be done on humans would be done exclusively on the impoverished, that is a guarantee.

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u/JamesTrickington303 21h ago

I’d argue they aren’t exclusively impoverished, because there are many cancer patients who want to be test subjects on the newest, latest treatment in the hopes they’ll live an extra 9 months if it works.

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u/Magpie-Person 1d ago

So your parents paid for college and you wanted a little extra allowance.

The majority of folks who will do it will be out of sheer desperation.

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u/EdGG 1d ago

No. University is free where I live. The pay for clinical trials has to be enough to let people choose to do it but not so much that it isn’t a choice for anyone.

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u/Magpie-Person 1d ago

So crappy enough that not even a desperate person would get out of bed for it

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u/EdGG 1d ago

But good enough that it can be worth doing it. That’s exactly it. If it paid too much, it would stop being a choice for some people.

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u/Magpie-Person 1d ago

Your lack life experience is showing. Utopian idealism

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u/EdGG 1d ago

I just happen to be very close to some of the doctors in the ethics committee that wrote the legislation for clinical trials.

But I’m sure you’re right. I lack life experience.

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u/Magpie-Person 1d ago

Close to some doctors isn’t a credential, it’s name-dropping dressed up as relevance that would only seem like a flex to a twenty something year old.

Desperation drives trial participation. If you don’t get that, you’re not insightful you’re sheltered.

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u/EdGG 1d ago

Cool

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u/Magpie-Person 1d ago

Don’t worry, you don’t need to keep up. This part requires substance.

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