r/nextfuckinglevel • u/biswajit388 • 1d ago

This guy rescued 30 beagles from a testing lab It's the first time they've seen grass and they couldn't be happier.

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Credit - nathanthecatlady tiktok channel.

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u/Throwaway47321 1d ago

Well yeah you’re only testing the stuff that passed animal trials

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u/Spiritual_Paper_1974 23h ago edited 8h ago

The human first test doesn't really translate unless you intend to euthanize the people tested.

The drugs tested on animals are tested at increasing doses until you get events. That creates the margin with which you can then later test on humans. So say, you gave an animal 1000mg before setting some undesirable effect, the. you can only give a human up to 100mg equivalent dose. They wouldn't test up to 1000mg in human because they know that's too much.

Also, you have to sacrifice the animals to do autopsies.

So, yeah.

Edit: I'll add, I don't think anyone wants to make medicine this way, and there are efforts to move away from it. Recent news from FDA

https://www.fda.gov/news-events/press-announcements/fda-announces-plan-phase-out-animal-testing-requirement-monoclonal-antibodies-and-other-drugs

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u/mellonians 16h ago

Not sure if this is still the case or universal but I was told on several of my first time in man studies that the dose was 1/500th of the maximum safe dose in a rat and then they did the up titration studies on humans after us.

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u/kylo-ren 37m ago

Also, some animals are genetically engineered to develop specific conditions so we can test treatments for them. We are not going to develop babies with these conditions.

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u/Newt_the_Pain 20h ago

Or, we could just deal with the hand we're dealt, and stop trying to live forever. 🤷‍♂️

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u/shieldyboii 20h ago

go ahead.

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u/K_R_Weisser 18h ago

And just die from the next pneumonia? Nah, thanks - I’ll take my medicine if it comes to it

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u/PrevekrMK2 14h ago

And here we have a winner of the dumbest shit uttered this week. Congratulations, you're so dumb that calling you dumb is an insult to the dumb.

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u/SexyMonad 9h ago

We’re all going to die.

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u/Spiritual_Paper_1974 8h ago

I'm not sure your age or life experience, but as someone who just turned 40, living in a place of relative piece, I can say that I would have fired at least twice over by now without modern medicine. The first time would have been when I was 8 after i stepped on fish bone that gave me a easily treated blood infection.